Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

This study is investigating the heart muscle changes that occur in people with heart failure with preserved ejection fraction (HFpEF) — a type of heart failure where the heart pumps normally but is too stiff to fill properly. Using advanced heart scans (MRI and echocardiography) and tissue samples, researchers want to understand why the heart behaves this way. **You may be eligible if...** - You are 30 or older - Your heart's pumping function (ejection fraction) is 50% or higher - You have been diagnosed with heart failure and have symptoms such as breathlessness, especially with elevated heart pressure or elevated BNP blood levels - Your symptoms fall in the mild to severe range (NYHA class II–IV) **You may NOT be eligible if...** - You have a different cause of heart muscle disease (such as amyloidosis, hypertrophic cardiomyopathy, or other specific cardiomyopathies) - You have had a recent heart attack or coronary surgery - You are unable to have an MRI or other required tests Talk to your doctor to see if this trial is right for you.