RecruitingNCT06517810

QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry

Pediatric Selective Cytopheretic Device (SCD-PED, QUELIMMUNE) for Critically Ill Children With Acute Kidney Injury: A Humanitarian Device Exemption (HDE) Surveillance Registry Protocol


Sponsor

SeaStar Medical

Enrollment

300 participants

Start Date

Jul 19, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT. The purpose of this surveillance registry is to prospectively collect safety data among all patients treated with QUELIMMUNE under the HDE. More specifically, we intend on comparing the incidence of new (secondary) blood stream infections in the first 28 days after SCD-PED initiation to a comparator group of matched CKRT patients with sepsis who did not receive treatment with QUELIMMUNE


Eligibility

Max Age: 22 Years

Inclusion Criteria1

  • All patients initiated on QUELIMMUNE therapy under the HDE-approved indication

Exclusion Criteria3

  • Weight \<10kg
  • Age \>22 years
  • Known allergy to any components of QUELIMMUNE

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Interventions

DEVICEQUELIMMUNE (SCD-PED)

QUELIMMUNE device used as part of clinical practice.


Locations(15)

Children's of Alabama

Birmingham, Alabama, United States

Lucile Packard Children's Hospital Stanford

Palo Alto, California, United States

UCSF Benioff Children's

San Francisco, California, United States

HealthONE HCA Rocky Mountain Children's Hospital

Denver, Colorado, United States

Children's Hospital of Atlanta - Arthur M. Blank

Atlanta, Georgia, United States

Children's Hospital of Atlanta - Scottish Rite

Atlanta, Georgia, United States

Lurie Children's Hospital of Chicago

Chicago, Illinois, United States

CS Mott Children's Hospital

Ann Arbor, Michigan, United States

Cincinnati Children's Hospital

Cincinnati, Ohio, United States

Cleveland Clinic Children's Hospital

Cleveland, Ohio, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Monroe Carrell Jr Children's Hospital at Vanderbilt

Nashville, Tennessee, United States

Children's Medical Center Dallas

Dallas, Texas, United States

Cook Children's Hospital

Fort Worth, Texas, United States

Texas Children's Hospital

Houston, Texas, United States

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NCT06517810


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