Axillary Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients With Initial cN1 Breast Cancer

This study is evaluating a less invasive approach to checking underarm (axillary) lymph nodes in people with early breast cancer who received chemotherapy before surgery. Rather than removing many lymph nodes, researchers are testing whether a targeted sentinel lymph node biopsy (removing only the key "sentinel" nodes) is accurate after chemotherapy has shrunk the cancer. **You may be eligible if...** - You are a patient with stage cT1–T3, N1, M0 breast cancer (cancer spread to 1–3 underarm lymph nodes, but not distant organs), confirmed by imaging - You had no more than 3 abnormal lymph nodes detected by imaging before treatment - You responded well to neoadjuvant (pre-surgery) chemotherapy (tumor showed complete or partial response) - Your performance status is good (ECOG 0–1) **You may NOT be eligible if...** - Your lymph node involvement was more extensive (more than 3 nodes) - You did not respond to pre-surgery chemotherapy - You have inflammatory breast cancer Talk to your doctor to see if this trial is right for you.