Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

This study (TRANSCEND) is testing whether a single guided session with psilocybin — the active compound found in "magic mushrooms" — combined with psychological support, can reduce chronic neuropathic pain (nerve pain lasting months or years) and depression in adults. The treatment is given in a supervised clinical setting. **You may be eligible if...** - You are 18–65 years old - You have chronic neuropathic pain (ongoing nerve pain) and depression - You are an outpatient (not currently hospitalized) - You can read and communicate in English well enough to understand consent forms and study questions - You are deemed capable of giving informed consent **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder with psychotic features - You are taking medications that interact with psilocybin (such as lithium or certain antidepressants) - You have active suicidal thoughts or intent - You are pregnant or breastfeeding - You have significant heart disease Talk to your doctor to see if this trial is right for you.