Efficacy of Mazdutide for Treating PCOS

This trial is testing whether mazdutide, a drug originally developed for weight management and diabetes, can help treat polycystic ovary syndrome (PCOS) — a hormonal condition that affects menstrual cycles and fertility. **You may be eligible if...** - You have a BMI of 28 or higher - You are not planning to become pregnant in the next 8 months - You meet the criteria for PCOS: irregular periods, polycystic ovaries on ultrasound, or elevated male hormones (at least 2 of 3 criteria) **You may NOT be eligible if...** - You have a history of pancreatitis - You or a family member has had medullary thyroid cancer or a condition called multiple endocrine neoplasia (MEN2) - Your triglycerides are severely elevated - You have type 1 or type 2 diabetes - You have another hormonal disorder causing PCOS-like symptoms (e.g., Cushing's syndrome, prolactinoma) - You are pregnant or breastfeeding - You have serious heart, liver, or kidney disease - You have any type of cancer Talk to your doctor to see if this trial is right for you.