RecruitingNot ApplicableNCT06519669

Autologous Tumor-Infiltrating Lymphocyte Injection(GT201) for Treatment of Patients with Advanced Lung Cancer

A Single-arm Clinical Study of Autologous Tumor-Infiltrating Lymphocyte (GT201 Injection ) for Treatment of Patients with Advanced Lung Cancer


Sponsor

Grit Biotechnology

Enrollment

40 participants

Start Date

Jul 18, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a single arm, open design aimed at evaluating the safety and tolerability of Autologous Tumor-Infiltrating Lymphocyte (GT201 injection ) for treatment of patients with Advanced lung cancer,while evaluating pharmacokinetic characteristics and efficacy assessment.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a personalized cell therapy called GT201 — where immune cells taken from a patient's own tumor (called tumor-infiltrating lymphocytes, or TILs) are grown in the lab and given back to fight the cancer — in people with advanced lung cancer. **You may be eligible if...** - You are between 18 and 70 years old - You have advanced non-small cell lung cancer (without certain driver gene mutations) that has not responded to first-line treatment, OR small cell lung cancer that has not responded to first-line treatment - You are in reasonably good health (ECOG score 0 or 1) - You have at least one measurable tumor that can be used to collect immune cells - Your life expectancy is at least 12 weeks **You may NOT be eligible if...** - You have uncontrolled cancer-related pain - You have a known mental illness, or a history of alcohol or drug abuse - You are pregnant, breastfeeding, or planning to become pregnant within 1 year - You received another experimental treatment within the past 4 weeks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALGT201 injection

GT201 injection to treat Advanced lung cancer


Locations(2)

Beijing GoBroad Hospital

Beijing, Beijing Municipality, China

Renji Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

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NCT06519669


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