Fiber and Calcium Absorption in Older Men
Modulation of the Gut Microbiome by Dietary Fiber to Improve Calcium Absorption and Bone Health in Older Men
VA Office of Research and Development
30 participants
Jan 1, 2025
INTERVENTIONAL
Conditions
Summary
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.
Eligibility
Inclusion Criteria1
- Male Veterans 60 years of age
Exclusion Criteria9
- History of malabsorption
- Hypercalcemia (corrected Ca > 10.2 mg/dL)
- Vitamin D insufficiency (25OHD < 30 ng/mL)
- Chronic kidney disease stage 3B or worse (CrCl < 45 mL/min)
- Severe hypogonadism (AM fasting serum total testosterone < 150 ng/dL)
- Daily use of proton pump inhibitor
- Use of medication(s) known to affect calcium metabolism
- Use of medications or supplements that could impact gut microbiota in the previous 3 months (antibiotics or commercially available probiotics or prebiotics.
- Presence of a condition or abnormality that in the opinion of the Investigator that would compromise the safety of the patient or the quality of the data.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Soluble corn fiber, also referred to resistant maltodextrin, is a type of dietary fiber made from corn starch. Soluble corn fiber is typically used to thicken processed foods and has been marketed as a prebiotic to improve digestive health.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06519877