RecruitingNot ApplicableNCT06522087

The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total Knee Replacement Arthroplasty in Elderly Patients.

The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total Knee Replacement Arthroplasty in Elderly Patients

Sponsor

Henan Provincial People's Hospital

Enrollment

110 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Anesthesia Elderly Postoperative Delirium

Summary

Delirium is an acute confusional state, it is a sign of acute encephalopathy, also known as acute brain failure, acute brain dysfunction or mental state changes.Postoperative delirium can cause post-traumatic stress disorder, affects patients' quality of life, extend the length of hospital stay, increased hospitalization cost, and is closely relative to short-term and long-term mortality after surgery. Exogenous 40 Hz stimulation can improve cognitive functioning. Therefore, the aim of this study was to investigate the effect of exogenous 40Hz stimulation on the incidence of postoperative delirium in elderly patients undergoing hip and knee replacement.

Eligibility

Min Age: 65 YearsMax Age: 85 Years

Inclusion Criteria1

65-85 years old, gender not limited 2.General anesthesia unilateral total hip replacement surgery or unilateral total knee replacement 3.ASA classification I-III 4.No drugs for mental and central nervous system diseases were used before surgery 5.Preoperative MMSE score illiterate > 17 points, primary > 20 points, junior high school and above > 24 points 6.Obtaining informed consent

Exclusion Criteria5

Severe liver and kidney dysfunction
here were mental and nervous system diseases before operation
Have a history of alcoholism, long-term use of sedative or analgesic
A history of a delirium and other reasons are reluctant to cooperate
Massive blood loss and blood transfusion during operation, prolonged operation time

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Interventions

DEVICE40Hz stimulation

Exogenous 40HZ stimulation is a physical intervention that can drive oscillations in the gamma range, and the oscillations and pulses caused at the corresponding frequency can lead to a significant reduction in β-amyloid, reverse tau hyperphosphorylation, and thereby improve the cognitive function of patients.