Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction
Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation
University of Houston
74 participants
Oct 1, 2024
INTERVENTIONAL
Conditions
Summary
The purposes of this study include: 1. \- To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke. 2. \- To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.
Eligibility
Inclusion Criteria9
- Male or female whose age range between 40 and 75
- no known neurological injuries
- male or female hemiparetic chronic stroke survivors;
- age ranging between 40-75 year;
- with single unilateral ischemic or hemorrhagic middle cerebral artery stroke;
- neurologically stable for >6 months;
- have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted;
- without severe spasticity (Modified Ashworth (MA) <4);
- have not received botulinum toxin on the impaired arm within 3 months.
Exclusion Criteria10
- have an orthopedic disorder involving upper limbs;
- have a history of any neurologic disease;
- have any history of epilepsy of the potential participants and/or their family members;
- are unable to consent;
- are pregnant.
- have an orthopedic disorder involving upper limbs;
- cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score < 26);
- a history of another neurologic disease;
- anesthesia of joint position sense in upper limbs;
- are pregnant or have a chance that they might be (self-reported);
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Interventions
During training exercise, post-stroke participants will be asked to match the targets on the screen. The experimental group will match them by activating a specific set of muscle. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.
During training exercise, post-stroke participants will be asked to match the targets on the screen. The active comparator group will match them by generating isometric force in a desired target direction. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06523335