Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression

This study is testing a brain stimulation technique called deep transcranial magnetic stimulation (deep TMS) as a treatment for bipolar depression. Unlike traditional antidepressants, deep TMS uses magnetic pulses to stimulate targeted regions of the brain. Researchers are also looking at whether this treatment affects thinking and memory. **You may be eligible if...** - You have a confirmed diagnosis of bipolar depression - You are between 18 and 65 years old - Your depression symptoms are moderate to severe (score of 17 or higher on a standard scale) - You have been on a stable medication regimen for at least 4 weeks before starting treatment **You may NOT be eligible if...** - You have a history of other psychiatric disorders, significant neurological disease, or severe brain injury - You have received electroconvulsive therapy or other brain stimulation treatments in the past 3 months - You have epilepsy, heart or blood vessel disorders, or metal implants in your head - You are currently experiencing manic or hypomanic symptoms - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.