The Cerebral and Cognitive Changes After Intermittent Theta Burst Stimulation (iTBS) Treatment for Depression

This study examines how a brain stimulation treatment called iTBS (intermittent theta burst stimulation) — a quick, non-invasive form of magnetic brain stimulation — affects the brain and thinking abilities of people with moderate depression. iTBS is delivered using a coil placed on the scalp and is already used as a treatment, but researchers want to understand exactly what brain changes it causes and whether these changes are linked to improvements in mood and thinking. **You may be eligible if...** - You have been diagnosed with at least moderate depression - Your current depressive episode has lasted more than 2 weeks but less than 2 years - Your medication has been stable for at least 3 weeks before starting treatment - You are able and willing to follow the treatment schedule and safely undergo MRI and brain stimulation **You may NOT be eligible if...** - Your depression is currently mild - Your depression is severe enough to require inpatient hospital care or electroconvulsive therapy (ECT) - Your depression appears to be triggered by grief or a major recent stressful event - You have bipolar disorder, borderline personality disorder, psychotic symptoms, current alcohol or substance abuse, eating disorders, OCD, or PTSD - You have a history of seizures or neurological conditions - You have a pacemaker or metal implants in your body - You are currently taking antipsychotic medications or benzodiazepines - You are pregnant Talk to your doctor to see if this trial is right for you.