RecruitingNot ApplicableNCT06735885

fMRI Neurofeedback With Matter Neuroscience App

Stanford-Matter Neuroscience High-Resolution fMRI Advanced Neurofeedback Feasibility Trial (fMRI Neurofeedback) Medical

Sponsor

Stanford University

Enrollment

240 participants

Start Date

Aug 12, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Depression Mild Depression Moderate

Summary

Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them. We hope to learn the safety and efficacy of neurofeedback for treating depression and lay the groundwork for a pivotal clinical trial.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brain training app that uses real-time brain scan feedback (called fMRI neurofeedback) to help people with mild to moderate depression learn to self-regulate their brain activity and improve their mood. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with major depressive disorder (MDD) without psychotic features - Your depression is mild to moderate (MADRS score 15–25) - You can read and understand English - You are willing to comply with all study procedures **You may NOT be eligible if...** - You have a history of psychosis or psychotic symptoms - Your depression is severe or very mild - You have conditions that prevent MRI scanning (e.g., metal implants) - You are unable to complete questionnaires in English Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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