RecruitingNCT06535451

Lung Cancer Screening Program in Mexico

Lung Cancer Early Detection With Low-dose Computed Tomography in High-risk Individuals: Experience in Mexico

Sponsor

Instituto Nacional de Cancerologia de Mexico

Enrollment

1,000 participants

Start Date

Mar 24, 2022

Study Type

OBSERVATIONAL

Conditions

Lung Cancer

Summary

This prospective study aims to detect early-stage lung cancer using low-dose computed tomography (LDCT) in Mexicans aged 50 or older who are current or former heavy smokers, non-smokers exposed to significant wood smoke, or diagnosed with COPD. Annual LDCT, spirometry, and serum biomarker tests will be conducted over 3 years, and a follow-up lasting up to 10 years.

Eligibility

Min Age: 50 Years

Inclusion Criteria5

Eligible participants over fifty years old and one of the next criteria:
Current smokers (\>20 pack-years)
Former smokers (\>20 pack-years) who have quit within the past 15 years,
Non-smokers exposed to wood smoke more than 100 hours/year
Patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD).

Exclusion Criteria6

Subjects who cannot be examined by tomography due to physical limitations such as weight.
History of any type of cancer within the last five years, except non-melanoma skin cancer.
Symptoms consistent with some malignant neoplasm.
People with a poor physical-emotional condition that reduces their life expectancy or does not ensure adherence to the study.
Elimination Criteria
• Withdrawal of informed consent

Interventions

OTHERScreening

Annual LDCT, lung function test (spirometry), anxiety/depression assessments, and serum biomarkers tests over 3 years. Follow-up will continue for 5 and 10 years or until event completion (cancer diagnosis, end of follow-up, or death).