RecruitingEarly Phase 1NCT06538311

Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

Neuromodulation of Brain Function in Alzheimer's Disease and Related Dementias


Sponsor

Massachusetts General Hospital

Enrollment

30 participants

Start Date

May 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.


Eligibility

Min Age: 40 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study tests transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique — as a treatment for people in the early stages of Alzheimer's disease or related memory conditions. TMS uses magnetic pulses to stimulate specific brain areas linked to memory. **You may be eligible if...** - You are aged 40–99 - You are a native English speaker - You have very mild or mild primary progressive aphasia (PPA), mild cognitive impairment, or are cognitively normal but have early Alzheimer's disease markers - You are willing to undergo brain imaging and neuropsychological testing **You may NOT be eligible if...** - You have had a significant head injury with loss of consciousness - You have another major neurological or psychiatric condition - You have a known brain lesion (e.g., tumor or stroke) - You have a pacemaker, metal implants, or other MRI contraindications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEActive rTMS

All study participants will receive one block of ACTIVE rTMS. Each block will consist of daily sessions of active rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).

DEVICESham rTMS

All study participants will receive one block of SHAM rTMS. Each block will consist of daily sessions of SHAM rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).


Locations(1)

Massachusetts General Hospital

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06538311


Related Trials