RecruitingNot ApplicableNCT06538337

Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers

Hypofractionated External Beam Radiotherapy With Adaptive Planning for Endometrial and Cervical Cancers (HERA Trial)


Sponsor

Jonsson Comprehensive Cancer Center

Enrollment

60 participants

Start Date

Jul 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

After surgery to remove the main endometrial and/or cervical tumor, most women receive radiation therapy. This study uses hypo-fractionated radiation therapy, which is a type of radiation therapy in which the total prescribed dose of radiation is delivered in fewer but larger doses than conventional or standard radiotherapy. This research study aims to determine if hypo-fractionated radiation therapy given after surgery can improve treatment tolerability (i.e., fewer treatments) with comparable side effects. Participants will be in the study for about 5 years: Radiation therapy: * 5 daily treatment sessions of MRI or CT-Guided Stereotactic Body Radiation Therapy (SBRT). * Each treatment session will occur on a weekday (typically consecutive weekdays) and will last approximately an hour. Treatment Follow-Up: * Check-up Appointment and answer questions at 3 months post RT * Check-up Appointments with physical exam every 6 months (+/- 4 weeks) for up to 5 years.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a streamlined radiation therapy approach (hypofractionation — fewer but slightly larger doses) with adaptive planning for women with endometrial or cervical cancer who need radiation after surgery. Adaptive planning means the radiation is adjusted to account for daily changes in the body. **You may be eligible if...** - You have confirmed endometrial or cervical cancer that has been surgically treated - You require adjuvant (post-surgical) pelvic radiation therapy as standard care - Your cancer is at an appropriate stage for radiation without concurrent chemotherapy - You are 18 or older in good overall health (ECOG 0–2) **You may NOT be eligible if...** - Your standard care calls for chemotherapy alongside radiation - You have another active cancer - You have had prior radiation to the same area Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONExternal beam Radiotherapy

Five fractions of radiation therapy using adaptive planning and CT or MRI guidance (6 Gy per fraction) delivered once every other day excluding weekends and holidays


Locations(1)

University of California at Los Angeles

Los Angeles, California, United States

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NCT06538337


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