RecruitingNot ApplicableNCT06538454

Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women

Acute and Chronic Effects of Resistance Training Intensity on Cardiovascular Parameters of Postmenopausal Women With Systemic Arterial Hypertension

Sponsor

University of Sao Paulo

Enrollment

24 participants

Start Date

Jul 23, 2024

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Diseases Arterial Hypertension Postmenopausal; Menorrhagia

Summary

The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH). The main research questions are: * Does the intensity of RT impact blood pressure (BP) in postmenopausal women with SAH? * How does RT intensity affect heart rate (HR) and their variability (HRV), endothelial function (EF), and nitric oxide (NO) biomarker synthesis in this population? * What are the effects of RT intensity on affectivity and rate of perceived exertion (RPE)? Researchers will compare two different intensities of RT (60% of the load for 1 repetition maximum \[1RM\] and 80% of 1RM) to determine their effects on the mentioned cardiovascular and perceptual parameters. Participants will: In the acute experiment: * Perform the same RT session in a crossover design, training with 60% of 1RM in one condition and 80% of 1RM in another condition * Have BP, HR, and HRV measured before, immediately after, and for one hour post-session * Report affectivity before each session and at the end, along with RPE In the chronic experiment: * Be randomized into two groups: one training with 60% of 1RM and the other with 80% of 1RM * Undergo a 10-week intervention period with evaluations before, during, and after the intervention * Have BP, HR, affective responses, and RPE measured at multiple time points * Have EF, HRV, and salivary concentrations of NO biomarkers assessed before and after the intervention

Eligibility

Sex: FEMALEMin Age: 50 YearsMax Age: 65 Years

Inclusion Criteria4

Women with 50 to 65 old years;
Postmenopausal diagnosis (amenorrhea for 12 months or more);
Previous diagnosis of hypertension and treat with medications;
Physically inactive.

Exclusion Criteria5

History of other cardiovascular problems (heart failure, heart attack, stroke, etc);
Grade II obesity (BMI ≥ 35 kg/m²);
Medications (beta-blockers and/or non-dihydropyridine calcium channel blockers);
Systolic blood pressure at rest above 160 mmHg and/or dyastolic blood presure above 105 mmHg;
Unable to perform resistance exercise due to musculoskeletal or cognitive reasons.

Interventions

BEHAVIORALResistance training

The exercises will be the same in both stages: squat, bench press, stiff, rowing, hip thrust and shoulder press. Futhermore, the rest interval (2 minutes) and the exercise order (alterning upper and lower limbs) also will be the same in the stages. In the chronic experiment, the resistance training will be carried for 10 weeks with 2 weekly sessions in alternate days. The sets in both groups will be carried close to muscle failure. The difference between groups is the intensity, who reflects the repetition zone. The 80%1RM group will be perform 8-10 repetitions per set, while the 60%1RM group will be perform 18-20 repetitions.