RecruitingNot ApplicableNCT06538454

Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women

Acute and Chronic Effects of Resistance Training Intensity on Cardiovascular Parameters of Postmenopausal Women With Systemic Arterial Hypertension


Sponsor

University of Sao Paulo

Enrollment

24 participants

Start Date

Jul 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH). The main research questions are: * Does the intensity of RT impact blood pressure (BP) in postmenopausal women with SAH? * How does RT intensity affect heart rate (HR) and their variability (HRV), endothelial function (EF), and nitric oxide (NO) biomarker synthesis in this population? * What are the effects of RT intensity on affectivity and rate of perceived exertion (RPE)? Researchers will compare two different intensities of RT (60% of the load for 1 repetition maximum \[1RM\] and 80% of 1RM) to determine their effects on the mentioned cardiovascular and perceptual parameters. Participants will: In the acute experiment: * Perform the same RT session in a crossover design, training with 60% of 1RM in one condition and 80% of 1RM in another condition * Have BP, HR, and HRV measured before, immediately after, and for one hour post-session * Report affectivity before each session and at the end, along with RPE In the chronic experiment: * Be randomized into two groups: one training with 60% of 1RM and the other with 80% of 1RM * Undergo a 10-week intervention period with evaluations before, during, and after the intervention * Have BP, HR, affective responses, and RPE measured at multiple time points * Have EF, HRV, and salivary concentrations of NO biomarkers assessed before and after the intervention


Eligibility

Sex: FEMALEMin Age: 50 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study compares different intensities of resistance (strength) training in postmenopausal women with high blood pressure to see which approach best improves cardiovascular health. High blood pressure after menopause is a major risk factor for heart disease in women. **You may be eligible if...** - You are a woman aged 50–65 - You have been diagnosed with menopause (no period for 12+ months) - You have a confirmed diagnosis of high blood pressure and are on medication for it - You are currently physically inactive **You may NOT be eligible if...** - You have other cardiovascular conditions (heart failure, prior heart attack, stroke) - You have Grade II obesity (BMI 35 or higher) - You take beta-blockers or certain calcium channel blockers - Your blood pressure at rest is severely elevated (above 160/105 mmHg) - You cannot perform resistance exercises due to physical or cognitive limitations Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALResistance training

The exercises will be the same in both stages: squat, bench press, stiff, rowing, hip thrust and shoulder press. Futhermore, the rest interval (2 minutes) and the exercise order (alterning upper and lower limbs) also will be the same in the stages. In the chronic experiment, the resistance training will be carried for 10 weeks with 2 weekly sessions in alternate days. The sets in both groups will be carried close to muscle failure. The difference between groups is the intensity, who reflects the repetition zone. The 80%1RM group will be perform 8-10 repetitions per set, while the 60%1RM group will be perform 18-20 repetitions.


Locations(1)

Laboratório de Fisiologia do Exercício e Metabolismo

Ribeirão Preto, São Paulo, Brazil

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NCT06538454


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