A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obstructive Jaundice

This trial is comparing two different approaches to draining bile (called biliary drainage) before surgery in people with pancreatic head cancer that is blocking the bile duct and causing severe jaundice (yellowing of the skin and eyes). The goal is to find the best method to safely lower bilirubin levels before the major surgery (Whipple procedure) takes place. **You may be eligible if...** - You have pancreatic head cancer (confirmed by pathology or multidisciplinary clinical diagnosis) causing severe obstructive jaundice - Your tumor appears resectable (removable by surgery) on imaging - Your bilirubin level is 250 µmol/L or higher and you have not had prior biliary drainage - You are 18–75 years old and reasonably functional (ECOG ≤ 2) **You may NOT be eligible if...** - You have another active cancer - Your cancer is not resectable - You have already had biliary drainage - Your organ function does not meet minimum requirements Talk to your doctor to see if this trial is right for you.