RecruitingEarly Phase 1NCT06541405

Safety and Efficacy of NK520 to Treat Pediatric Relapsed/Refractory Acute Myeloid Leukemia

An Open, Single Center Exploratory Study to Evaluate Safety and Efficacy of NK520 for Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia


Sponsor

Base Therapeutics (Shanghai) Co., Ltd.

Enrollment

9 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the safety and efficacy of NK520 in the treatment of pediatric relapsed/refractory acute myeloid leukemia. NK520 will be administered by intravenous injection. The safety and efficacy of this treatment will be evaluated.


Eligibility

Min Age: 6 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a new cell therapy called NK520 — made from natural killer (NK) immune cells — for children and teenagers with relapsed or refractory acute myeloid leukemia (AML), a type of blood cancer that starts in the bone marrow. NK520 aims to use the body's own immune system to destroy leukemia cells. **You may be eligible if...** - You are between 6 and 18 years old with a confirmed diagnosis of AML - Your leukemia has relapsed (come back after remission) or is refractory (not responding to at least 2 prior treatment regimens) - You are not eligible for other currently available treatments **You may NOT be eligible if...** - You are younger than 6 or older than 18 - Your leukemia does not meet the WHO criteria for AML - You have certain other serious health conditions - Your organ function does not meet minimum safety thresholds Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNK520

The number of NK520 cell infused for each dosing should be calculated base on the body weight of subject. NK520 will be administered through intravenous infusion.


Locations(1)

Shanghai Children's Medical Center

Shanghai, Shanghai Municipality, China

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NCT06541405


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