RecruitingEarly Phase 1NCT06541444

Safety and Efficacy of NK520 to Treat Relapsed/Refractory Acute Myeloid Leukemia

An Open, Single Center Exploratory Study to Evaluate Safety and Efficacy of NK520 for Patients With Relapsed/Refractory Acute Myeloid Leukemia


Sponsor

Base Therapeutics (Shanghai) Co., Ltd.

Enrollment

9 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study will evaluate the safety and efficacy of NK520 in the treatment of relapsed/refractory acute myeloid leukemia. NK520 will be administered by intravenous injection. The safety and efficacy of this treatment will be evaluated.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing NK520 — a natural killer (NK) cell therapy — for adults with relapsed or refractory acute myeloid leukemia (AML) that has not responded to or has come back after at least 2 lines of treatment. It is the adult version of a similar pediatric trial testing the same therapy. **You may be eligible if...** - You are 18–75 years old with a confirmed diagnosis of AML - Your leukemia has relapsed or is refractory (not responding to treatment) after at least 2 prior treatment regimens - You are not a candidate for other currently available therapies **You may NOT be eligible if...** - You are younger than 18 or older than 75 - Your diagnosis does not meet WHO criteria for AML - You have serious organ dysfunction or other conditions preventing safe participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNK520

The number of NK520 cell infused for each dosing will be calculated based on body weight of subject. NK520 should be administered through intravenous infusion once a week, for a total of four times.


Locations(1)

Shanghai Pudong Hospital

Shanghai, Shanghai Municipality, China

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NCT06541444


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