RecruitingNCT06541626

Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases

Sun Yat-Sen Prospective Cohort Study of Central Nervous System Idiopathic Inflammatory Demyelinating Diseases

Sponsor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Enrollment

450 participants

Start Date

Jan 1, 2024

Study Type

OBSERVATIONAL

Conditions

Clinically Isolated Syndrome Acute Disseminated Encephalomyelitis Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease Neuromyelitis Optica Spectrum Disorders Multiple Sclerosis (MS)Demyelinating Disorder

Summary

The goal of this observational study is to learn about pathogenesis and clinical prognosis of CNS IIDD in the Chinese population and to provide evidence-based clues for clinical treatment decisions. The main questions it aims to answer are: Question 1: Clarify the clinical characteristics and prognostic factors of various diseases (MS, NMOSD, MOGAD, etc.) within IIDD in the Chinese population. Question 2: Analyze the relationship between biomarkers and the occurrence, progression, and prognosis of CNS IIDD cases in our hospital. Participants will 1. Receive the recommended diagnosis and treatment plans from current international and national guidelines or expert consensus, without additional special interventions. 2. Receive clinical evaluation, follow-up, and management from dedicated neuroimmunology specialists.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is building a long-term patient registry at Sun Yat-Sen University to track people with inflammatory diseases of the brain and spinal cord (central nervous system demyelinating diseases). Conditions such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and related conditions cause the immune system to mistakenly attack the protective covering of nerve fibers. The registry will help researchers understand how these diseases progress over time. **You may be eligible if...** - You are 18–65 years old with a central nervous system inflammatory demyelinating disease (such as MS, NMOSD, MOGAD, or ADEM) - You agree to participate and sign informed consent **You may NOT be eligible if...** - You have a brain or spinal cord tumor - Your neurological symptoms are due to infection, genetic, metabolic, toxic, or vascular causes - You are unwilling or unable to comply with the study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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