RecruitingNot ApplicableNCT06541756

Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears

Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears - A Prospectively Randomized Controlled Trial


Sponsor

Ankara City Hospital Bilkent

Enrollment

120 participants

Start Date

Jul 25, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Longitudinal meniscal tears are a type of meniscal injury characterized by a displaced fragment of the meniscus that flips over into the joint, often resembling a buckle or handle. These tears typically occur in the medial meniscus and are often associated with traumatic knee injuries, particularly in athletes. The displaced meniscal fragment can cause mechanical symptoms such as locking, clicking, or catching of the knee, as well as pain and swelling. If not properly treated, buckle-handle meniscal tears can lead to further complications, including chronic knee instability, increased risk of osteoarthritis, and persistent joint pain.Repairing a longitudinal meniscal tear offers several advantages over partial meniscectomy, particularly in preserving knee function and preventing long-term complications. Meniscal repair aims to restore the integrity of the meniscus, which plays a crucial role in load distribution, shock absorption, and joint stability. Utilizing a fibrin clot during the repair of a buckle-handle meniscal tear can enhance the healing process and improve surgical outcomes. Fibrin clots act as a biological scaffold, promoting tissue regeneration by providing a matrix that facilitates cellular migration and proliferation. The purpose of this study was to compare longitudinal meniscal tear repair reinforced with fibrin clot with routine end-to-end repair in a prospective randomized controlled trial.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria4

  • Presenting with a painful meniscus (lateral or medial) longitudinal tear
  • Being between the ages of 18 and 50
  • Not having undergone surgery on the same knee before
  • Having an MRI taken at the end of the 1st year post-surgery

Exclusion Criteria5

  • Having additional collateral ligamentous damage along with the meniscus tear (such as MCL or LCL)
  • Incomplete clinical scores at the end of the study
  • A history of previous surgery on the same knee
  • Having an active infection
  • Not having a control MRI at the end of the 1st year

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Interventions

PROCEDUREFibrine Clot-augmented Meniscal Repair

The fibrin clot will be prepared from 50cc of bone marrow aspirate obtained from the iliac crest and mixed for 15 minutes. The fibrin clot will be shaped into a cylindrical form and compressed between the torn edges of the meniscus using a trocar system, then secured with sutures.

PROCEDUREConventional Meniscal Repair

Patients in the standard repair group will undergo routine meniscus repair surgery using arthroscopic all-inside or inside-out sutures.


Locations(2)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Ankara Etlik City Hospital

Ankara, Turkey (Türkiye)

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NCT06541756


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