Knee injuries Clinical Trials

23 recruitingLast updated: May 11, 2026

There are 23 actively recruiting knee injuries clinical trials across 9 countries. Studies span Not Applicable, Early Phase 1, Phase 3, Phase 4. Top locations include Ankara, Turkey (Türkiye), Edina, Minnesota, United States, Bologna, Italy. Updated daily from ClinicalTrials.gov.


Knee injuries Trials at a Glance

23 actively recruiting trials for knee injuries are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Ankara, Edina, and Bologna. Lead sponsors running knee injuries studies include Istituto Ortopedico Rizzoli, Kırklareli University, and Twin Cities Orthopedics.

Browse knee injuries trials by phase

Treatments under study

About Knee injuries Clinical Trials

Looking for clinical trials for Knee injuries? There are currently 22 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Knee injuries trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Knee injuries clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 23 trials

Recruiting

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

Physical InactivityAgingAthletic Injuries+1 more
Marquette University450 enrolled1 locationNCT05344001
Recruiting
Phase 4

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Knee injuriesOpioid UsePain, Postoperative
Sanford Health148 enrolled1 locationNCT03858231
Recruiting

Establishing the Clinical Significance Values of the Lysholm Knee Score

Knee injuries
Kırklareli University69 enrolled1 locationNCT06571227
Recruiting

Validity and Reliability of the Turkish Version of the Tegner Activity Score

Knee injuries
Kırklareli University69 enrolled1 locationNCT06571240
Recruiting
Not Applicable

Comparison Between the Use of the Tensioner and Standard Surgical Technique for Ligament Balancing of Total Knee Prostheses

Knee injuries
Istituto Ortopedico Rizzoli200 enrolled1 locationNCT06770153
Recruiting
Not Applicable

Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

Knee injuriesPain, PostoperativeShoulder Injuries
Stanford University76 enrolled1 locationNCT04109638
Recruiting
Not Applicable

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

Knee injuriesQuadriceps Muscle AtrophyAnterior Cruciate Ligament Injuries
Connecticut Children's Medical Center40 enrolled1 locationNCT05754632
Recruiting

Clinical and Instrumental Assessment of Meniscal ROOT Tears Treated Through Suture to the Posterior Cruciate Ligament

Knee injuriesMeniscus TearMeniscus Lesion
Istituto Ortopedico Rizzoli59 enrolled1 locationNCT06507241
Recruiting

Correlation Between Psychological Readiness, Knee Function, and Isokinetic Performance After Anterior Cruciate Ligament Reconstruction (ACLR) Using Peroneus Longus Tendon Graft (PL-ACL-2025)

Knee injuriesAthletic InjuriesAnterior Cruciate Ligament (ACL) Injury
Cairo University52 enrolled1 locationNCT07201597
Recruiting
Not Applicable

Fibrine Clot-augmented Repair of Longitudinal Meniscus Tears

Knee injuriesMeniscus TearMeniscus Lesion+1 more
Ankara City Hospital Bilkent120 enrolled2 locationsNCT06541756
Recruiting

Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated "Stener-like" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures

Knee injuriesLigament Injury
Stefano Zaffagnini43 enrolled1 locationNCT07174219
Recruiting
Not Applicable

Fixation of Patellar Tendon Grafts in Anterior Cruciate Ligament Reconstruction. Endobutton vs Metal Interference Screws

Knee injuries
St. Olavs Hospital220 enrolled2 locationsNCT02918734
Recruiting
Not Applicable

Blood Flow Restriction Training After Patellar INStability

Knee injuriesWounds and InjuriesPatellar Dislocation+1 more
Caitlin Conley78 enrolled4 locationsNCT04554212
Recruiting
Not Applicable

Gait Rehabilitation to Treat FastOA

Knee injuriesKnee OsteoarthritisOsteo Arthritis Knee+4 more
University of North Carolina, Chapel Hill70 enrolled1 locationNCT05848622
Recruiting

SportsPro: Post-Market Clinical Follow Up Study

Knee injuriesShoulder InjuriesHip Injuries
Stryker Endoscopy1,500 enrolled3 locationsNCT06320925
Recruiting
Phase 3

Dronabinol After Arthroscopic Surgery

Knee injuriesKnee OsteoarthritisMeniscus Tear+5 more
Northwestern University30 enrolled1 locationNCT05335252
Recruiting
Not Applicable

OrthoPureXT Multiligament PMCF Study

Multiligament Knee Injuries
Tissue Regenix Ltd28 enrolled1 locationNCT05655156
Recruiting
Not Applicable

Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction

Knee injuries
Twin Cities Orthopedics50 enrolled1 locationNCT05073263
Recruiting
Not Applicable

Non- Vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction

Knee injuries
Twin Cities Orthopedics50 enrolled1 locationNCT05073276
Recruiting

Knee Osteoarthritis in the Region of Norrbotten

Knee injuriesQuality of LifePatient Satisfaction+5 more
Umeå University500 enrolled1 locationNCT06451510