RecruitingNot ApplicableNCT06542978

Effect of Prophylactic Application of 40Hz Transcranial Stimulation in AICU on Incidence of Postoperative Delirium in Elderly Patients Undergoing Elective Gastrointestinal Surgery

Sponsor

Henan Provincial People's Hospital

Enrollment

98 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Anesthesia Elderly Postoperative Delirium

Summary

Postoperative delirium is an acute central nervous system dysfunction caused by surgical stress, which is manifested by postoperative acute, non-specific changes in consciousness level, attention, cognitive ability and disturbance of sleep and wake cycles. It is one of the most common surgical complications in the elderly, occurring in more than 75% of patients receiving mechanical ventilation in the intensive care unit(ICU).Exogenous 40 Hz stimulation can improve cognitive functioning.Therefore, the aim of this study was to investigate the effect of exogenous 40Hz stimulation on the incidence of postoperative delirium in elderly patients undergoing elective gastrointestinal surgery in AICU.

Eligibility

Min Age: 65 Years

Inclusion Criteria3

Age ≥ 65 years old,gender not limited
ASA classification Ⅱ ~ Ⅳ
Elective gastrointestinal general anesthesia surgery

Exclusion Criteria6

History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis
Pre-operative coma, severe dementia, speech impairment or severe illness incapacitated and unable to communicate
Delirium on admission or pre-operative delirium, brain injury
Severely infected person
Severe liver dysfunction (Child-Pugh C), severe renal insufficiency (preoperative dialysis)
Severe hearing or vision impairment

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Interventions

DEVICE40Hz stimulation

Exogenous 40HZ stimulation is a physical intervention that can drive oscillations in the gamma range, and the oscillations and pulses caused at the corresponding frequency can lead to a significant reduction in β-amyloid, reverse tau hyperphosphorylation, and thereby improve the cognitive function of patients.