RecruitingPhase 1NCT06543667

Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye

A Clinical Study for Safety and Efficacy Evaluation of Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye Syndrome


Sponsor

Iran University of Medical Sciences

Enrollment

30 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of eye drop made from tiny particles (exosomes) derived from stem cells on the surface of the eye, to see if it can help people with moderate to severe dry eye disease. **You may be eligible if...** - You are 18–70 years old - You experience symptoms of dry eye such as burning, itching, or a gritty sensation - You have moderate or severe dry eye disease **You may NOT be eligible if...** - You have had previous eye surgery - You have a condition that weakens the immune system - You are pregnant or breastfeeding - You have eyelid abnormalities - You have used eye drops (other than artificial tears) in the past year - You have worn contact lenses in the last 3 months - You have taken medications that affect tear production in the last 3 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALLimbal Stem Cell Derived Exosomes Eye Drop

Patients will receive artificial tears for 2 weeks to get the normalized baseline, followed by LSC-Exo eye drops 0.15 ml/single eye/one time, four times a day for 3 months. The follow-up visit will be 12 weeks since the administration of LSC-Exo eye drops.


Locations(1)

Moheb Kowsar Hospital

Tehran, Iran

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NCT06543667


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