RecruitingNot ApplicableNCT06545045

Cognitive Rehabilitation Following Breast Cancer Treatment

Pilot Testing of Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer

Sponsor

University of Missouri-Columbia

Enrollment

50 participants

Start Date

Oct 31, 2024

Study Type

INTERVENTIONAL

Conditions

Breast Cancer Female

Summary

The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a brain rehabilitation program designed to help breast cancer survivors who are experiencing cognitive difficulties — often described as "chemo brain" — such as memory lapses, trouble concentrating, and mental fatigue. **You may be eligible if...** - You have completed treatment for stage I, II, or III invasive breast cancer at least 6 months ago (but not more than 3 years ago) - You are experiencing noticeable cognitive problems (memory, attention, or mental clarity issues) - You can read, write, and speak English fluently - Your medications affecting cognitive function have been stable for at least 90 days **You may NOT be eligible if...** - You have had another cancer diagnosis with active disease in the past year - You have an active psychiatric condition that would interfere with the program - You have a life expectancy of less than 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMetacognitive Strategy Training (MCST)

The MCST group will follow procedures for the Cognitive Orientation to daily Occupational Performance intervention. First, five functional, everyday life goals are identified collaboratively by the participant and interventionist. In the second meeting, the therapist introduces the approach to the subject and teach a global cognitive strategy (i.e., GOAL-PLAN-DO-CHECK). In all subsequent sessions, this strategy is used as the main problem-solving framework to facilitate skill acquisition. The subject identifies a GOAL, and then is guided by the therapist to discover a PLAN to potentially achieve the goal. The subject is then asked to DO the plan (if feasible during the therapy session otherwise asked to complete at home prior to the next treatment session), and subsequently to CHECK to see if the plan worked, i.e. the goal was achieved. This process is repeated until satisfactory performance is met for each established goal.

BEHAVIORALInactive Control Group

Weekly contact will be made via telephone call to (1) maintain study engagement, (2) introduce weekly social contact with researchers, mimicking some of the potential incidental effects of the experimental group, and (3) ascertain what, if any, additional steps participants have taken to reduce cognitive symptoms. The content of each of these meetings will be tracked in intervention notes.