The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
The Effect of Melatonin Supplementation on Cumulus Cells and Reproductive Outcomes in Older Women Undergoing IVF Cycles
Kaohsiung Veterans General Hospital.
200 participants
May 1, 2021
INTERVENTIONAL
Conditions
Summary
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.
Eligibility
Inclusion Criteria3
- Age 35-45 years
- BMI 18-30 kg/m2
- planning to undergo IVF cycles
Exclusion Criteria8
- Primary ovarian insufficiency
- history of oophorectomy
- receiving oocyte donation
- Chromosome anomaly
- Congenital uterine anomaly
- Severe intrauterine adhesion
- Malignancy
- Using hormone therapy or supplements in recent 3 months
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Interventions
In the study group, patients will receive melatonin supplementation for at least two months prior to IVF cycles
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06546774