Effects of LH and FSH on Metabolic Regulation in Cumulus Cells
Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells
Kaohsiung Veterans General Hospital.
60 participants
Dec 1, 2024
INTERVENTIONAL
Conditions
Summary
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
Eligibility
Inclusion Criteria3
- Age 35-40 years
- BMI 18-30 kg/m2
- planning to undergo IVF cycles
Exclusion Criteria8
- Primary ovarian insufficiency
- history of oophorectomy
- receiving oocyte donation
- Chromosome anomaly
- Congenital uterine anomaly
- Severe intrauterine adhesion
- Malignancy
- Using hormone therapy or supplements in recent 3 months
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Interventions
In the study group, participants receive FSH and LH in IVF cycle
In the control group, participants receive FSH alone in IVF cycle
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06803199