RecruitingNCT06548269

Multimodal Prognostic Assessment of Acute Ischemic Stroke Patients With Atrial Fibrillation: a Prospective, Multicenter, Observational Study (IAT-CLOSURE)

Sponsor

Jinan Central Hospital

Enrollment

1,000 participants

Start Date

Nov 15, 2024

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation Acute Ischemic Stroke

Summary

The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \[oral anticoagulation\], antiplatelet \[APT\]) and left atrial appendage closure \[LAAC\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multimodal assessment from combined brain and cardiologic work-up, and to optimize secondary prevention.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age \> 18 years old；
Acute ischemic stroke with onset ≤ 14 days；
Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation;
Informed consent obtained from the patient or his/her legal representative；

Exclusion Criteria8

Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor;
Left atrial appendage has been removed or post occlusion device implantation;
Transient AF secondary to other reversible disorders；
Life expectancy less than 1 year;
Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.);
Females who are pregnant or in lactation;
Participating in other clinical trials that could confound the evaluation of the study;
Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.

Interventions

DIAGNOSTIC_TESTCardiologic work-up

Noninvasive prolonged ECG monitoring with a duration of 7 days measuring AF burden； Echocardiography measuring LA volume or volume index, LA diameter or diameter index； Cardiac CTA measuring LAA morphologies, cardiac thrombus.