Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases

This study is testing a cutting-edge immune therapy called CAR-T cell therapy — where a patient's own immune cells are reprogrammed to attack disease — for people with serious autoimmune diseases. The CAR-T cells are designed to target CD19 or both CD19 and BCMA proteins found on the immune cells that are mistakenly attacking the body. **You may be eligible if...** - You are between 18 and 70 years old with a confirmed autoimmune disease - Your liver, kidney, blood, and heart function meet the required levels - Your oxygen levels are acceptable - You have tried other treatments without success **You may NOT be eligible if...** - You have active uncontrolled infections, including HIV or hepatitis - You have had a prior organ transplant or stem cell transplant - You are pregnant or breastfeeding - You have severe heart or lung problems - You have active cancer - Your organ function is too impaired for this intensive therapy Talk to your doctor to see if this trial is right for you.