Ixovex-1 Single Agent and Combination Therapy

This is an early-phase trial testing a new drug called Ixovex-1, given either alone or in combination with other therapies, for people with solid tumors (cancers that form in organs or tissues, rather than the blood). Ixovex-1 is injected directly into the tumor. The study is mainly focused on safety and finding the right dosage. **You may be eligible if...** - You are 18 years of age or older - You have a solid tumor that is locally advanced, unresectable (cannot be surgically removed), or has spread (metastatic) - Your tumor can be reached for direct injection - You have tried standard therapies and they have not worked or are not available - Your general health and organ function meet the study requirements **You may NOT be eligible if...** - Your tumor is not accessible for injection - You have serious infections or autoimmune diseases - You have had recent major surgery or are currently receiving certain other therapies that would conflict - You are pregnant or breastfeeding - You have significant heart, liver, or kidney problems Talk to your doctor to see if this trial is right for you.