High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
Chinese University of Hong Kong
66 participants
Sep 1, 2024
INTERVENTIONAL
Conditions
Summary
Patients with focal epilepsy often have diagnostic difficulties as their culprit for seizures are difficult to be picked up using conventional imaging. The current study is to investigate the utility of advanced MRI sequences on detection of subtle lesions accountable for focal epilepsy.
Eligibility
Inclusion Criteria6
- Consecutive patients with drug-resistant focal epilepsy fulfilling the following criteria -
- \. Diagnosis of focal epilepsy with a probable site identified, as defined by concordant results from any TWO of the following:
- Clinical seminology compatible with focal epilepsy.
- Electroencephalography pointing towards a specific site for focal epilepsy.
- Positive ictal brain scintigraphy with SPECT-CT correlation. AND 2. Previous MRI (at least one study with protocol tailored for epilepsy) which did not reveal accountable focal lesion.
- AND 3. Able to consent for MRI examination (if patient under age of 18, consent for MRI will be obtained from guardian). Patients will be provided information leaflets to read on, and written consent before taking part in this study and MRI examination.
Exclusion Criteria3
- Patients who are contraindicated to magnetic resonance imaging (such as due to underlying MRI incompatible metallic implants)
- Patients who cannot cooperate for MRI scanning.
- Patients show are unable to provide informed consent.
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Interventions
Subjects will undergo MRI scanning in our 3T machine with dedicated high resolution sequences (including 2D T1-weighted inversion recovery sequences, 3D FLAIR MRI whole brain, 3D T1-weighted Sagittal MPRAGE; plus other sequences for the clinical purpose of pre-operative planning as per consensus with referring doctor)
Locations(1)
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NCT06550726