Treating Postictal Symptoms Using Ibuprofen and Nifedipine
An Initial Clinical Study to Treat Postictal Symptoms
University of Calgary
90 participants
Feb 1, 2021
INTERVENTIONAL
Conditions
Summary
This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo.
Eligibility
Inclusion Criteria1
- age \> 16 yrs, frequent seizures (\>1 per week) and cognitive ability sufficient to complete neuropsychological testing.
Exclusion Criteria1
- multiple seizure onset zones, contraindications to CT or MR imaging, any contraindication to ibuprofen or nifedipine, as well as current or recent (\< 2 months) exposure COX-2 inhibitor or calcium channel blocker.
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Interventions
Ibuprofen to be prepared in a tablet that is not distinguishable from nifedipine or placebo tablet.
Nifedipine to be prepared in a tablet that is not distinguishable from ibuprofen or placebo tablet.
Sugar pill to be prepared in a tablet that is not distinguishable from ibuprofen or nifedipine tablet.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03949478