RecruitingNot ApplicableNCT06551090

Prediction of Anxiety and Memory State

Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State


Sponsor

Columbia University

Enrollment

40 participants

Start Date

Jul 23, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system for measuring human brain-behavior relationships. The R61 portion of the project is designed to develop the CAMERA platform, which will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy, as well as to build CAMERA's passive data framework and active data framework.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how anxiety and memory states affect brain activity in people with temporal lobe epilepsy — a form of epilepsy that originates in the memory and emotion centers of the brain. Researchers will use electrodes temporarily placed in the brain (during a procedure already planned for epilepsy care) to measure brain signals while participants complete simple tasks. **You may be eligible if...** - You have known or suspected temporal lobe epilepsy - You speak English or Spanish fluently - You can read at approximately a 7th grade level - Your planned brain monitoring will include electrodes in the hippocampus (memory area) **You may NOT be eligible if...** - You have uncorrected hearing or vision problems - You have an IQ below 70 - You have a history of psychosis, electroconvulsive therapy, or active anxiety, depression, or bipolar disorder - You have a neurodegenerative disease, HIV, cancer with spread potential, or kidney failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCAMERA (Context-Aware Multimodal Ecological Research and Assessment)

The CAMERA platform is a multimodal, hardware-software framework for measuring brain-behavior interactions in an unstructured environment and predict ecological states. CAMERA will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy. CAMERA consists of: Wristband sensors of autonomic physiologic signals, emphasizing heart rate metrics and electrodermal activity; Smartphone usage, emphasizing natural language processing of text input for linguistic features; Subject-tracking audiovisual array, emphasizing subject vocal activity; Intracranial neural recordings, emphasizing hippocampal theta power and high-frequency activity (\~70-200 Hz).


Locations(1)

Columbia University Irving Medical Center

New York, New York, United States

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NCT06551090


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