RecruitingNot ApplicableNCT06551090

Prediction of Anxiety and Memory State

Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State

Sponsor

Columbia University

Enrollment

40 participants

Start Date

Jul 23, 2024

Study Type

INTERVENTIONAL

Conditions

Epilepsy Anxiety Memory

Summary

The purpose of this study is to look at how signals in the brain, body, and behavior relate to anxiety and memory function. This project seeks to develop the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, a state-of-the-art open multimodal hardware/software system for measuring human brain-behavior relationships. The R61 portion of the project is designed to develop the CAMERA platform, which will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy, as well as to build CAMERA's passive data framework and active data framework.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria4

Patients must have known or suspected Temporal Lobe Epilepsy.
Native or proficient in speaking English or Spanish.
Stereoelectroencephalography (sEEG) cases: The implant plan must include hippocampal head, body, and tail electrodes either unilaterally or bilaterally.
th grade reading level (minimum level considered literate for adults)

Exclusion Criteria9

Hearing impaired (i.e., not corrected with a hearing aid)
Unable to read the newspaper at arm's length with corrective lenses.
Objective intellectual impairment (estimated IQ \< 70)
Any history of Electroconvulsive Therapy or psychosis (except postictal psychosis for patients)
Psychotic disorder (lifetime)
Current Anxiety disorder, Major Depressive Disorder, or Bipolar Disorder
Neurodegenerative diseases, presence of widespread brain lesions, language problems (other than naming difficulty)
Medical conditions that could potentially affect cognitive performance (e.g., human immunodeficiency virus (HIV) infection, cancer with metastatic potential).
Acute renal failure or end-stage renal disease

Interventions

OTHERCAMERA (Context-Aware Multimodal Ecological Research and Assessment)

The CAMERA platform is a multimodal, hardware-software framework for measuring brain-behavior interactions in an unstructured environment and predict ecological states. CAMERA will use multimodal, passive sensor data to predict anxiety-memory state in patients undergoing inpatient monitoring with intracranial electrodes for clinical epilepsy. CAMERA consists of: Wristband sensors of autonomic physiologic signals, emphasizing heart rate metrics and electrodermal activity; Smartphone usage, emphasizing natural language processing of text input for linguistic features; Subject-tracking audiovisual array, emphasizing subject vocal activity; Intracranial neural recordings, emphasizing hippocampal theta power and high-frequency activity (\~70-200 Hz).