RecruitingNot ApplicableNCT06551311

The Effects of Eccentric Cycling Exercise Program in Chronic Kidney Disease Patients

To Explore Efficacy and Load of Eccentric Cycling Training in Older CKD Patients with or Without Sarcopenia

Sponsor

National Cheng Kung University

Enrollment

90 participants

Start Date

Jul 1, 2023

Study Type

INTERVENTIONAL

Conditions

Chronic Kidney Disease

Summary

Progress in medical technology, enhancements in environmental cleanliness, and elevated living conditions have notably prolonged the mean life expectancy, resulting in a swift increase in the aging population. The prevalence of Chronic Kidney Disease (CKD) is more pronounced among the elderly in contrast to younger demographics. With the aging of the CKD population, the capacity to autonomously handle daily activities becomes a critical concern. This demographic frequently encounters concurrent health conditions, a decrease in self-care capabilities, general health decline, and diminished quality of life. Recent studies suggest that physical activity has the potential to enhance cardiovascular health, cardiopulmonary endurance, muscle strength, quality of life, uremic toxin management, and inflammation levels among individuals with CKD. Given that CKD patients often exhibit sedentary behavior and reduced exercise capacity, eccentric cycling exercises may be particularly well-suited for this demographic. Compared to concentric contractions, eccentric contractions subject the muscles to higher tension. Since muscle growth partially depends on the "stress exerted on muscle fibers"-meaning the greater the stress, the more stimulation the muscles receive-training focused on eccentric contractions could provide more stimulation and promote greater muscle growth. In recent studies, eccentric cycling has emerged as a feasible and promising aerobic exercise intervention. It can provide a safe and appropriate amount of exercise while relatively reducing joint pressure. This novel combined aerobic and anaerobic exercise method is particularly beneficial for individuals with weaker lower limb muscles, lower joint pressure tolerance, poor metabolic and cardiovascular function, and a tendency to fatigue.

Eligibility

Min Age: 55 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a type of backward-pedaling (eccentric) cycling exercise program can improve strength, fitness, and quality of life in people with chronic kidney disease (CKD). Eccentric cycling puts less strain on the heart than traditional exercise, making it potentially safer for people with reduced kidney function. **You may be eligible if...** - You have been diagnosed with chronic kidney disease (CKD) - Your kidney function is significantly reduced (eGFR below 60) or you are on regular dialysis - You can walk independently and communicate normally **You may NOT be eligible if...** - You have acute (sudden) kidney failure - You were hospitalized for a serious illness in the last 3 months - You have severe joint disease or had recent lower limb surgery - You have severe neurological or cardiovascular disease - You are unconscious or unable to cooperate with assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALcycling training exercise

Participants were randomly allocated to one of three groups: control (CTL), concentric cycling training (CON), or eccentric cycling training (ECC). CTL: Received standard health education guidance. CON and ECC: Participants in both the CON and ECC groups engaged in 24 exercise sessions, performed three times per week, lasting between 20 and 30 minutes. Both groups trained on a stationary bicycle, with the CON group performing concentric cycling and the ECC group performing eccentric cycling. The exercise intensity for both groups was set to a rating of perceived exertion (RPE) level of 13. Sessions began at 20 minutes and increased incrementally by 3-5 minutes each week until participants could sustain a 30-minute duration. The initial exercise intensity was set at 50% of the maximal output determined by a cardiopulmonary exercise test, and it was progressively increased by 5-10% of the estimated target power weekly, with adjustments made primarily to maintain an RPE of 13.