RecruitingPhase 1NCT06553898

Study of Therapeutic Efficacy of CAR-T Cell Therapy in Patients With MDR-SRNS

Study of Therapeutic Efficacy of Anti-B Cell Maturation Antigen(BCMA)/Cluster of Differentiation 70(CD70 )CAR-T Cells in Patients With Multi-drug Resistant SRNS


Sponsor

The Children's Hospital of Zhejiang University School of Medicine

Enrollment

18 participants

Start Date

Aug 13, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is an investigator-initiated trial aimed at assessing the safety and efficacy of anti-BCMA/CD70 CAR-T cells in the treatment of patients with Multi-drug resistant SRNS


Eligibility

Min Age: 2 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called anti-BCMA/CD70 CAR-T cells for people with car-t cell therapy and multi-drug resistant nephrotic syndrome. The study is currently recruiting participants at 1 location. People eligible for this study include aged 2 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALanti-BCMA/CD70 CAR-T cells

Three dose groups (0.3×105/kg, 1×105/kg, 3×105/kg) were set up, starting from the low dose group climbing to explore the safe and effective dose.


Locations(1)

Children's Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT06553898


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