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RecruitingNot ApplicableNCT06554470

Local vs Systemic Methotrexate in Management of Uterine Ectopic Pregnancy

Local Versus Systemic Methotrexate in Management of Uterine Ectopic Pregnancy: A Randomized Trial

Sponsor

Tanta University

Enrollment

34 participants

Start Date

Aug 15, 2024

Study Type

INTERVENTIONAL

Conditions

MethotrexateLocalSystemicUterine Ectopic Pregnancy

Summary

This study aims to compare local and systemic methotrexate in the management of uterine ectopic pregnancy regarding the duration of beta human chorionic gonadotropin (hCG) clearance and need for further management options.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 40 Years

Inclusion Criteria3

  • Age from 20 to 40 years.
  • Women with uterine ectopic pregnancy (interstitial pregnancy, cervical pregnancy, or cesarean scar pregnancy).
  • Gestational age is less than 9 weeks, the embryo size is smaller than 10 mm, and the serum beta-human chorionic gonadotropin (β-hCG) levels are less than 10,000 mIU/mL.

Exclusion Criteria7

  • Patients with basal beta hCG levels less than 1500 mIU/Ml.
  • Any contraindications to MTX as a hepatic disorder, renal disorder and thrombocytopenia
  • Diabetes mellitus.
  • Severe vaginal bleeding or hemodynamic changes or hemoperitoneum.
  • History of cancer.
  • Ascites.
  • Pleural effusion.
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Interventions

DRUGSystemic Methotrexate

Patients will receive systemic methotrexate (intramuscular; 50 mg/m2 body weight).

DRUGLocal Methotrexate

Patients will receive local methotrexate (25 mg methotrexate as a fixed dose).

Locations(1)

Tanta University

Tanta, El-Gharbia, Egypt

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NCT06554470

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