Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Boston Children's Hospital
25 participants
Oct 23, 2025
INTERVENTIONAL
Conditions
Summary
Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being. This study proposes to test the feasibility and acceptability of a resilience-promoting intervention through a Collaborative Care Model. The primary goal is to determine with the resilience intervention (PRISM) is feasible and acceptable for adolescents and young adults with SCD. Exploratory outcomes include whether this intervention improves depression, anxiety, and pain interference.
Eligibility
Inclusion Criteria8
- Aged ≥ 12 and ≤ 25 years of age at baseline
- Diagnosed with Sickle Cell Disease (HbSS, HbSC, HbS-Beta Thalassemia, and other related hemoglobinopathies)
- Receiving Medical Care at the DFCI/BCH Blood Disorders Center.
- Scored > 9 on Patient Health Questionnaire 9-item (PHQ-9) or Generalized Anxiety Disorder (GAD)
- Able to speak English or Spanish language (for PRISM sessions)
- Able to read English or Spanish language (for completion of surveys)
- Cognitively able to participate in PRISM sessions and complete written questionnaires and surveys, as judged by the site investigator
- Willing and able to adhere to the study visit schedule and other protocol requirements
Exclusion Criteria1
- * does not meet above criteria
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
The interprofessional team will meet weekly to review survey scores, endorsed psychological and physical health needs, as well as other concerns. They will conduct assessments as a group that may include referrals for additional support.
PRISM targets 4 resilience resources: stress management, goal-setting, cognitive reframing and meaning-making. It is delivered one-on-one by trained coaches in English or Spanish via HIPAA compliant video-conference or in-person. Sessions are delivered every 1-2 weeks based on patient preference. To facilitate practice between sessions, all participants 13 or older have access to the digital PRISM app.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06555939