Focused Research On Neurofeedback Therapy In Eradicating Depression (FRONTIER)

This study (called FRONTIER) is testing a brain-training technique called neurofeedback — where you can see real-time information about your own brain activity and learn to regulate it — as a treatment for depression in people who have not fully recovered with antidepressants alone. **You may be eligible if...** - You are 18 or older and have been diagnosed with major depressive disorder - Your depression is at least moderate severity (based on standardized rating scales) - You are currently taking antidepressants and willing to continue them during the study, OR you are not currently on antidepressants - You are being treated by a psychiatrist - You can have MRI scans (no metal implants, no claustrophobia) **You may NOT be eligible if...** - You have active suicidal thoughts or a history of suicide attempts - You have been hospitalized for depression - You have a history of seizures, epilepsy, or significant brain disease - You have a drug or alcohol addiction - You are pregnant or not willing to use contraception - You are participating in another clinical trial Talk to your doctor to see if this trial is right for you.