Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

This study compares ketamine infusion combined with psychotherapy sessions to ketamine infusion alone for treating moderate-to-severe depression, to find out whether the therapy component adds meaningful benefit. **You may be eligible if...** - You are aged 18–90 with a current diagnosis of major depressive disorder - Your depression is at least moderate in severity - You are in generally good physical health - You may remain on your current antidepressant medications at a stable dose **You may NOT be eligible if...** - You have a history of schizophrenia, bipolar disorder, or psychosis - You have a substance use disorder in the past 12 months - You have used ketamine recreationally in the past year or have not responded to ketamine before - You are pregnant, breastfeeding, or have significant heart or blood pressure issues - You have significant suicidal ideation or a recent suicide attempt - Your BMI is over 35 Talk to your doctor to see if this trial is right for you.