RecruitingPhase 3NCT07592689

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Ascend


Sponsor

Definium Therapeutics US, Inc.

Enrollment

165 participants

Start Date

May 10, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend


Eligibility

Min Age: 18 YearsMax Age: 74 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called DT120 and Placebo for people with major depressive disorder. The study is currently recruiting participants at 27 locations. People eligible for this study include aged 18 Years to 74 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPlacebo

A substance that is designed to have no therapeutic value

DRUGDT120

A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A)


Locations(32)

Lighthouse Psychiatry

Gilbert, Arizona, United States

Preferred Research Partners, Inc.

Little Rock, Arkansas, United States

ATP Clinical Research Orange County

Orange, California, United States

Kadima Neuropsychiatry Institute

San Diego, California, United States

UCSF Department of Neurology

San Francisco, California, United States

Psychedelic Science Institute

Santa Monica, California, United States

Mountain View Clinical Research, Inc

Denver, Colorado, United States

Clinical Neuroscience Solutions, Inc (Jacksonville)

Jacksonville, Florida, United States

K2 Medical Research (Maitland)

Maitland, Florida, United States

Clinical Neuroscience Solutions, Inc (Orlando)

Orlando, Florida, United States

Charter Research

Orlando, Florida, United States

K2 Medical Research (Tampa)

Tampa, Florida, United States

CenExel - Atlanta Center for Medical Research

Atlanta, Georgia, United States

CenExel - iResearch Atlanta

Decatur, Georgia, United States

CenExel - iResearch Savannah

Savannah, Georgia, United States

Uptown Research Institute

Chicago, Illinois, United States

Adams Clinical Boston

Boston, Massachusetts, United States

Adams Clinical Watertown

Boston, Massachusetts, United States

Vitalix Clinical

Worcester, Massachusetts, United States

Arch Clinical Trials, LLC

St Louis, Missouri, United States

Redbird Research

Las Vegas, Nevada, United States

CenExel - Marlton

Marlton, New Jersey, United States

Adams Clinical Harlem

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

Adams Clinical Philadelphia

Philadelphia, Pennsylvania, United States

Coastal Carolina Research

North Charleston, South Carolina, United States

Austin Clinical Trial Partners

Austin, Texas, United States

Cedar Clinical Research

Draper, Utah, United States

Inner Space Research

Orem, Utah, United States

Memory Clinic Inc.

Bennington, Vermont, United States

Seattle Neuropsychiatric Treatment Center

Seattle, Washington, United States

VA Portland Healthcare System

Vancouver, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT07592689


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