Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
Effectiveness of Gut Microbiota-targeted Diatery Intervention in Preventing Atherosclerotic Cardiovascular Disease Among Older People Living With HIV
Fudan University
110 participants
Aug 20, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in preventing ASCVD among older people living with HIV (PLWH).
Eligibility
Inclusion Criteria6
- HIV-infected patients diagnosed according to the diagnostic criteria of China AIDS diagnosis and treatment guidelines;
- Aged 40 years and above;
- at risk of CVD: having any two of those risk factors: dyslipidemia, DM or elevated blood glucose, smoking, hypertention or elevated blood pressure, metabolic syndrome,overweight/obesity; or PCE score\>5%,
- Those with a predicted survival time of \>1 year;
- No plans to leave the depth in the next 3 months;
- Voluntary participation in this study and signing the informed consent
Exclusion Criteria7
- Those with a previous history of CVD;
- Those with HIV-related neurocognitive impairment, Alzheimer's disease or dementia, and a variety of serious opportunistic infections;
- Currently suffering from malignant tumors, gastrointestinal diseases; People with an aversion to eating;
- Allergic to nuts and fish;
- People who take medicinal calcium \>1000 mg per day or omega-3 supplements;
- Plan to become pregnant within 6 months;
- Are participating in other HIV-related or dietary intervention-related scientific research programs.
Interventions
The dietary intervention targeted at gut microbiota. Each participant's dietary habits,food preferences and economic level were taken into account. The dietary intervention was delivered by sending meals. To ensure the freshness and quality of the ingredients, 2 dedicated researchers were jointly responsible for the procurement of fresh ingredients, which were purchased through regular channels on Monday, Wednesday and Friday mornings. Meals will be delivered three times a week for a 12-week intervention period. Guided dietary follow-up was conducted through WeChat or telephone follow-up. The researcher will provide cooking instruction or dietary pattern guidance every two weeks.
Locations(1)
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NCT06560840