A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Adult ALL

This study is comparing two types of stem cell transplant conditioning regimens in adults aged 18–65 with acute lymphoblastic leukemia (ALL) who are in complete remission and undergoing a haploidentical transplant — where the donor is a half-matched family member (such as a parent or sibling) rather than a perfect match. **You may be eligible if...** - You are age 18–65 and have been diagnosed with ALL (blood cancer) - Your leukemia is in complete remission - You have a haploidentical (half-matched) donor available, such as a parent or sibling - You are in good health overall (Karnofsky score ≥70) - Your heart, liver, kidney, and lung function are within acceptable ranges **You may NOT be eligible if...** - Your leukemia is not in complete remission - You do not have a suitable donor - You have significant organ impairment - You have active, uncontrolled infection - You have previously undergone a stem cell transplant Talk to your doctor to see if this trial is right for you.