The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Exclusion Criteria13

• Individuals who are pregnant or breastfeeding
• Prisoners
• Adults unable to consent
• Those with a nut allergy or tocopherol allergy
• Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
• Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
• Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
• Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
• Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
• Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
• Antioxidant ingredients such as vitamin C or vitamin E.
• Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
• Topicals that contain a nut oil or nut extract as part of their ingredient list.