Pigmentation Clinical Trials

26 recruitingLast updated: July 25, 2026

There are 26 actively recruiting pigmentation clinical trials across 12 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1. Top locations include Sacramento, California, United States, Cairo, Egypt, Al Fayyum, Egypt. Updated daily from ClinicalTrials.gov.


Pigmentation Trials at a Glance

26 actively recruiting trials for pigmentation are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 17 trials, with the heaviest enrollment activity in Sacramento, Cairo, and Al Fayyum. Lead sponsors running pigmentation studies include Cairo University, Al-Azhar University, and Cosmetique Active International.

Browse pigmentation trials by phase

Treatments under study

About Pigmentation Clinical Trials

Looking for clinical trials for Pigmentation? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pigmentation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pigmentation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 26 trials

Recruiting
Not Applicable

Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation

DepigmentationDepigmentation Treatment
Al-Azhar University20 enrolled1 locationNCT07677826
Recruiting
Not Applicable

A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants

MelasmaPost-inflammatory HyperpigmentationSolar Lentigo
Kenvue Brands LLC152 enrolled1 locationNCT07679945
Recruiting

National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases

AniridiaAlbinismCorneal Dystrophy+4 more
National Eye Institute (NEI)1,000 enrolled2 locationsNCT06491615
Recruiting
Not Applicable

Study on the Functional Impact of Cosmetics on Improving Self-Esteem and Quality of Life in Black Women

Post-inflammatory Hyperpigmentation
Hospital Israelita Albert Einstein60 enrolled1 locationNCT07618572
Recruiting
Phase 2

Gingival Hyperpigmentation Treatment

Gingival PigmentationVitamin CGlutathione+1 more
Cairo University30 enrolled1 locationNCT07595705
Recruiting
Not Applicable

Vitamin C for Gingival Depigmentation

Gingival HyperpigmentationGingival Melanin Pigmentation
Al-Azhar University30 enrolled1 locationNCT07513727
Recruiting
Not Applicable

Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation

Gingival Hyperpigmentation
Cairo University20 enrolled1 locationNCT07402720
Recruiting

The Impact of Skin Tone on Pulse Oximeter Accuracy

Accuracy of Pulse Oximetry Across Skin Pigmentation Levels
Rush University Medical Center194 enrolled1 locationNCT07415187
Recruiting
Not Applicable

Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.

Gingival PigmentationGingival Hyperpigmentaion
Fayoum University30 enrolled1 locationNCT07410156
Recruiting
Not Applicable

Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation

Gingival Pigmentation
Cairo University32 enrolled3 locationsNCT07359339
Recruiting
Phase 4

Prospective Evaluation of Topical Almond Oil vs Hydroquinone

Skin Pigmentation
University of California, Davis50 enrolled1 locationNCT04875715
Recruiting

Pulse Oximeter Accuracy in Healthy Humans During Hypoxia

HypoxiaSkin Pigmentation
University of California, San Francisco10,000 enrolled1 locationNCT06142019
Recruiting
Not Applicable

The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation

Hyperpigmentation
Chulalongkorn University30 enrolled1 locationNCT07067879
Recruiting
Not Applicable

Characterization of Bacterial and Mycosis Skin Flora in Seborrheic Macular Hypopigmentation - Microbiome

Hypopigmentation
Centre Hospitalier Universitaire de Nice20 enrolled3 locationsNCT06908889
Recruiting
Phase 1Phase 2

Autologous Adipose Cells Therapy

Hair ThinningHair Loss/BaldnessWrinkle Appearance+5 more
CERM INC.40 enrolled2 locationsNCT06869252
Recruiting
Not Applicable

Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color

HyperpigmentationAcne Scars - Mixed Atrophic and HypertrophicLaser-Induced Hyperpigmentation
Albert Einstein College of Medicine46 enrolled1 locationNCT05362929
Recruiting
Not Applicable

The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

WrinkleCollagen DegenerationPigmentation+2 more
Integrative Skin Science and Research90 enrolled1 locationNCT06571721
Recruiting
Not Applicable

Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins

Hyperpigmentation
Cosmetique Active International72 enrolled1 locationNCT06253468
Recruiting
Not Applicable

Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins

Hyperpigmentation
Cosmetique Active International60 enrolled1 locationNCT06268496
Recruiting
Not Applicable

The Effects of Almond on Facial Skin Collagen and Wrinkles

WrinkleCollagen DegenerationPigmentation+1 more
Integrative Skin Science and Research60 enrolled1 locationNCT06074276