RecruitingNot ApplicableNCT06572280

Non-invasive Phrenic Nerve Stimulation in ARDS Patient

Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study


Sponsor

Southeast University, China

Enrollment

10 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is investigating a non-invasive technique called percutaneous phrenic nerve stimulation to help keep the diaphragm (the main breathing muscle) active in patients with acute respiratory distress syndrome (ARDS) who are on mechanical ventilators. When patients rely on ventilators, the diaphragm can weaken from disuse, which may make it harder to breathe independently and recover. The study tests whether stimulating the phrenic nerve through the skin, synchronized with the ventilator, can prevent this muscle loss and improve outcomes. You may be eligible if you are an adult ARDS patient on a controlled ventilator within 48 hours of being intubated, without pacemakers, metallic implants, or nerve/spinal cord conditions. Participation involves receiving the stimulation treatment while in intensive care and being closely monitored. This summary was prepared using AI to help patients understand this research.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEPNS group

non-invasive phrenic nerve stimulation


Locations(1)

Zhongda Hospital, School of Medicine, Southeast University

Nanjing, Jiangsu, China

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NCT06572280


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