RecruitingNCT06574282

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

The COHIR Multi-center Study - a Non-interventional, Prospective, Multi-center Investigation With Exploratory Data Analysis to Assess the Proportion of Patients With Hypophosphatasia Presenting at the Department of Rheumatology and Establishment of an Algorithm to HPP Diagnosis.


Sponsor

University of Bonn

Enrollment

720 participants

Start Date

Aug 25, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Written informed consent
  • Age > 18 years
  • Clinical suspicion of hypophosphatasia
  • Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

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Interventions

DIAGNOSTIC_TESTSecond alkaline phosphatase measurement

(1-4 weeks after the 1st measurement)


Locations(1)

Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn

Bonn, North Rhine-Westphali, Germany

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NCT06574282


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