RecruitingNCT06575881

Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Defining the Risk of Ventricular Tachycardia in Genetic Forms of Early-onset Atrial Fibrillation

Sponsor

Vanderbilt University Medical Center

Enrollment

200 participants

Start Date

Dec 13, 2023

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation Ventricular Tachycardia Premature Ventricular Contraction

Summary

The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy. Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at what causes certain inherited heart conditions to trigger a dangerous fast heart rhythm called ventricular tachycardia (VT). Researchers want to better understand who is at risk so they can prevent sudden cardiac events. **You may be eligible if...** - You are 18 years or older - You were diagnosed with atrial fibrillation (irregular heartbeat), frequent abnormal heartbeats (PVCs), or VT before age 60 - You are scheduled for a catheter ablation procedure (a heart procedure to correct abnormal rhythms) - You carry a genetic variant in certain heart genes (like TTN, DSP, PKP2, DSG2, DSC2, LMNA, or PLN) **You may NOT be eligible if...** - You are unable to give written consent - You do not meet the genetic or procedural criteria Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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