RecruitingPhase 3NCT06576375

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome: A Prospective Comparative Randomized Blinded Trial.

Sponsor

Future University in Egypt

Enrollment

70 participants

Start Date

Sep 2, 2024

Study Type

INTERVENTIONAL

Conditions

Polycystic Ovary Syndrome

Summary

In PCOS (Polycystic Ovary Syndrome), studies have found impaired incretin secretion and activity, particularly in overweight/obese individuals. Conflicting results exist regarding glucagon-like peptide-1(GLP-1) levels in PCOS patients, with studies reporting reduced, normal, or increased levels. Incretin-based therapy has been suggested as a potential treatment to reverse prediabetes risk by preserving β-cell function in patients with impaired fasting glucose(IFG and impaired glucose tolerance(IGT). The study aims to compare the efficacy of Dapagliflozin to Metformin for the treatment of non-diabetic patients with polycystic ovary syndrome (PCOS).

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two medications — dapagliflozin (commonly used for diabetes) and metformin — to see which is more effective for treating polycystic ovary syndrome (PCOS) in women who are struggling to get pregnant. **You may be eligible if...** - You are a woman between 18 and 40 years old diagnosed with PCOS - You are experiencing infertility (primary or secondary) **You may NOT be eligible if...** - You have type 1 or type 2 diabetes - You have liver or kidney problems, autoimmune disease, cancer, or a recent heart event - You are using hormonal medications or contraceptives - You are already pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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