RecruitingNot ApplicableNCT06576700

Effect of Procyanidins in Leaky Gut Repairing in IBD

Effect of Procyanidins in the Leaky Gut Repairing Associated with Inflammatory Bowel Disease

Sponsor

University of Padova

Enrollment

25 participants

Start Date

Jun 15, 2024

Study Type

INTERVENTIONAL

Conditions

Ulcerative Colitis in Remission

Summary

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are: Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life? Participants will: Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether procyanidins — plant-based compounds found in foods like grapes and blueberries — can help repair the gut lining ("leaky gut") in people with ulcerative colitis (UC) who are currently in remission. **You may be eligible if...** - You have been diagnosed with ulcerative colitis, confirmed by colonoscopy and tissue biopsy - Your UC is currently in remission (not in a flare) - You are between 18 and 75 years old **You may NOT be eligible if...** - Your UC is currently active (in a flare) - You have Crohn's disease or another type of inflammatory bowel condition - You are pregnant or breastfeeding - You have serious other health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALGrape Seed Extracts

2 capsules/day for 8 weeks

Locations(1)

Edoardo Vincenzo Savarino

Padua, Padua, Italy

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NCT06576700

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