Photoacoustic Tomography in Assessment of Lower Extremity Artery Disease
Multistructural Quantitative Photoacoustic Imaging of Human Feet With Lower Extremity Artery Disease
Sun Yat-sen University
200 participants
Nov 1, 2024
OBSERVATIONAL
Conditions
Summary
Lower extremity artery disease (LEAD) is characterized by low awareness rate and high missed diagnosis rate, leading to low treatment rate and high disabling mortality rate. However, none of the current examination methods can comprehensively and thoroughly evaluate the vascular structure and blood oxygen status of the lower extremity at the same time. Photoacoustic imaging can display millimeter-scale microvessels without the need for contrast agents. The investigators developed photoacoustic tomography (PACT) technology, which wass able to provide three-dimensional and high-resolution photoacoustic images of the target area.The investigators plan to recruit LEAD patients in different disease conditions and healthy volunteers to receive the PACT examination on the feet using this imaging system, and to evaluate the potential clinical role of the imaging system in LEAD, and its added value to current imaging methods.
Eligibility
Inclusion Criteria2
- Inclusion of the case group 1) LEAD patients; 2) Patients voluntarily take part in the study and write informed consent.
- Inclusion of the control group 1) Patients without LEAD by ultrasound and clinical diagnosis; 2) Patients voluntarily take part in the study and write informed consent.
Exclusion Criteria6
- age <18 years;
- pregnant women, nursing mothers and pregnant women in preparation;
- with laser operation contraindication (for example, received a photodynamic therapy in the last month);
- with metal implants in lower legs or feet;
- with a history of mental illnesses or abuse of drug and alcohol;
- \) with blood phobia or pathological hypotension; 8) with cerebral hemorrhage or peripheral vascular bleeding risk, or history of stroke; 9) with wounds in lower legs or feet; 10) unable or uncooperative with the experimenter.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
It could provide three-dimensional ultrasound images of vessels in the target area. It could also provides super-resolution and large-depth photoacoustic images. By effectively extracting photoacoustic spectral features and using spectral feature unmixing algorithm, blood oxygen saturation can be calculated.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06579326